The Arizona Cardinals Football Club has announced its 2021 regular season schedule, presented by SeatGeek.
The regular season schedule includes three nationally televised, prime-time games during the regular season and another in the preseason. Each of those four games will be played at State Farm Stadium.
The prime-time regular season games are a Thursday night home tilt versus Green Bay on Oct. 28, a Monday night visit from the Rams on Dec. 13, and a Saturday night matchup with the Colts that marks just the third all-time Christmas game for the Cardinals (1995 and 2010).
Three prime-time home games is the most ever for the Cardinals in a regular season (also in 1995, 1999, 2015 and 2016).
The 2021 regular season will be the league’s first since expanding to 17 games. The NFL had played a 16-game slate since 1978 and before that had a 14-game regular season from 1961-77.
In addition to traditional home and away games against the NFC West, the Cardinals take on the AFC South (Houston, Indianapolis, Jacksonville and Tennessee) and the NFC North (Chicago, Detroit, Green Bay and Minnesota).
The 2021 season is the team’s 16th at State Farm Stadium, where the Cardinals have created one of the NFL’s best home-field advantages.
Single-game tickets for Cardinals home games are now available by visiting azcardinals.com/gametix.
Regular season schedule
Week 1 at Tennessee (Sept. 12): For the first time since 1997 at Cincinatti, the Cards open the season on the road against an AFC team. New Cards cornerback Malcolm Butler faces the team with which he spent the last three seasons. It will be the 12th all-time meeting between the clubs (Arizona leads 7-4).
Week 2 versus Minnesota (Sept. 19): The Cards face the Vikings for the 10th time in 16 years, this time in the home opener, which is good, as the home team has won the last seven contests in the series. Cornerback Patrick Peterson returns to State Farm Stadium, where he starred for 10 years with the Cardinals.
Week 3 at Jacksonville (Sept. 26): Arizona plays in Jacksonville for the first time since earning a victory there in 2013. The Jags are led by new head coach Urban Meyer and rookie quarterback Trevor Lawrence, who — like Kyler Murray in 2019 — was the No. 1 overall pick in the NFL Draft last month.
Week 4 at LA Rams (Oct. 3): The Cards play their first divisional game when they travel to the site of this year’s Super Bowl, SoFi Stadium. Matthew Stafford — who faced the Cards eight times as the Lions quarterback and was 3-4-1 — takes on Arizona for the first time with his new squad.
Week 5 versus San Francisco (Oct. 10): It’s back-to-back division games for the Cards, this time at home versus San Francisco, where they have an 8-7 series edge. San Francisco will be back in the role of visitors after hosting three games at State Farm Stadium last season due to COVID-19 restrictions in California.
Week 6 at Cleveland (Oct. 17): This game was added when the regular season expanded to 17 games. The Cards are looking for their fifth straight win over the Browns. The most recent came in a 2019 showdown of Oklahoma Heisman winners when Kyler Murray topped Baker Mayfield in Arizona.
Week 7 versus Houston (Oct. 24): Arizona stars DeAndre Hopkins and J.J. Watt — who combined to earn nine Pro Bowl selections in Houston — face their former team for the first time when the Texans come to Arizona. It’s just the fifth all-time meeting; the home team has won each previous (two per side).
Week 8 versus Green Bay (Oct. 28): The Packers come to town for a nationally televised Thursday night game. It’s Green Bay’s first visit to State Farm Stadium since the unforgettable Divisional Playoff game in 2016 that Arizona won on Larry Fitzgerald’s touchdown in overtime after an Aaron Rodgers Hail Mary.
Week 9 at San Francisco (Nov. 7): It’s just the third NFC West matchup of the year for Arizona but the second against the 49ers. This time the Cards travel to Levi’s Stadium, where they have won five of the last six contests played there and are 5-2 overall.
Week 10 versus Carolina (Nov. 14): The Cards and Panthers meet for their 16th regular season game ever and the seventh time in the last nine years, including postseason. The teams have split the last four meetings in Arizona.
Week 11 at Seattle (Nov. 21): Arizona heads to Seattle with a 4-2 record in its last six visits to Lumen Field. The Cards have more wins there (eight) than any other NFL team since the venue opened in 2002. Since 2013, the Seahawks are 3-5 at home versus Arizona and 42-14 against the rest of the NFL.
Week 12 bye: The Cards have had a later bye week just one time: 1991, when it fell in Week 14 (Dec. 1).
Week 13 at Chicago (Dec. 5): The only original franchises remaining from the NFL’s founding in 1920 renew their rivalry when the Cardinals and Bears meet for the 92nd time. The Cards return to Soldier Field — the NFL’s oldest venue — for the first time since a 48-23 win there in 2015.
Week 14 versus LA Rams (Dec. 13): Monday Night Football returns to State Farm Stadium when the Rams come to town for an NFC West showdown. It will be the Cards’ 28th all-time appearance on MNF. Their most recent was a year ago in Dallas, when they earned a 38-10 win over the Cowboys.
Week 15 at Detroit (Dec. 19): The Cards head to Motown for their 16th Lions matchup since 2002 realignment (Arizona’s most against any nondivisional foe in that span). They will see new Lions head coach Dan Campbell and familiar quarterback Jared Goff, formerly of the Rams.
Week 16 versus Indianapolis (Dec. 25): On a Christmas Saturday night at State Farm Stadium, the Cards host the Colts in a game that will air nationally on NFL Network. Arizona has won the last two versus Indy, including a 40-11 victory in the Colts’ last visit to Arizona in 2013.
Week 17 at Dallas (Jan. 2): Kyler Murray returns to AT&T Stadium, where he has a perfect 7-0 record (NFL, college and high school). One of them was Arizona’s 38-10 win on MNF in 2020. A victory this season would be Arizona’s third straight road win over Dallas, its longest such streak since 1961-64.
Week 18 versus Seattle (Jan. 9): The Cards close the regular season versus Seattle for the sixth time since 2008 and fourth time at home. Last year’s Seahawks game at State Farm Stadium was a thrilling 37-34 Cardinals win in overtime on Sunday Night Football that also came a week after playing at Dallas.